Bioidentical Hormone Pellets

What is Bioidentical Hormone Pellet Therapy?

Once the decision is made to use hormone therapy, there comes another decision: Which method is the best fit for you? For some women, hormone pellet therapy is considered a superior method of hormone delivery. With this unique system, 2-3 small pellets consisting of testosterone or estradiol, each about the size of a grain of rice, are inserted beneath the skin, into the fatty tissue of the hip, and the pure hormone is delivered gradually, directly into the bloodstream. The simple in-office procedure takes only a few minutes, first with numbing of the skin, and one tiny incision that only requires a small steri strip, no stitches.

The subcutaneous pellets act as a reservoir of hormone, allowing the body to receive a consistent dose throughout the day and night. The pellets gradually absorb until they are completely dissolved, leaving no residue. Typically, a woman will find that pellets will control symptoms for 4-6 months. Because of the efficient and gradual delivery system of the hormone pellets, side effects are less likely than with oral or injectable hormones, and there is less incidence of issues related to poor absorption, sometimes problematic with hormone creams, gels, or patches.

Bioidentical hormone pellets are FDA monitored, but not approved in the United States. Hormone pellet therapy has been used in both men and women for decades in Europe and Australia, and this has allowed for the generation of ample scientific data regarding the benefits and safety of this method. Hormone pellet therapy is being used more and more in the US, as women seek a more convenient and natural way to receive their hormone therapy.

Testosterone Pellet Therapy:

Testosterone is a vital hormone in women, eliciting physiologic effects through androgen receptors in almost all female body tissues, including breast, heart, blood vessels, intestines, lungs, brain, spinal cord, nerves, bladder, uterus, ovaries, endocrine glands, vaginal tissue, skin, bone, joints, and fatty tissue.

Men produce higher circulating levels of testosterone than women; however, testosterone is the most abundant active sex hormone in a woman throughout her lifespan. Testosterone has been considered a “male hormone”, thus largely ignored as an essential hormone in female physiology. This has been unfortunate, since attention has not been given to diminished quality of life and potential health consequences when women begin to experience symptoms related to testosterone decline in mid life. In a woman’s body, production of testosterone peaks in her mid 20’s and begins to steadily decline, down to about 50% by age 40. This is when a woman will often present with complaints such as increased abdominal fat, hair loss, fatigue, brain fog, loss of sex drive, reduced orgasm, anxiety, irritability, depression, headaches, and general lack of well-being. Most women attribute these symptoms to a natural diminishment of vitality with aging. But, recognizing these symptoms are signaling something about our bodies, and giving attention to hormone health can improve our health and quality of life as we age.
Testosterone replacement therapy for symptomatic women has the potential to improve mood, libido, orgasm, energy level, and feeling of well-being. In addition, documented health benefits include reduced cardiac risk, reduced breast cancer risk, and improved bone density. Testosterone therapy can be beneficial for symptomatic individuals as early as a decade or more before onset of the menopause transition.

It is important to note that in both men and women, testosterone can be converted within the body’s tissues to estradiol, some of which is not measurable, as conversion takes place within cells where it immediately binds with its receptor. Interestingly, it has been demonstrated that breast cancer survivors using testosterone pellet therapy, combined with medication that blocks conversion of testosterone to estradiol, reported relief of menopausal symptoms with testosterone therapy alone. Thus, for some women, testosterone pellet therapy will be all that is required to control symptoms. For others, the addition of estradiol and progesterone will be of benefit. Each woman will be individually evaluated, and appropriate options considered.

Estradiol Pellet Therapy:

Estradiol is the estrogen hormone that makes a woman look female and governs much of reproductive function. This hormone also plays a role in countless bodily functions, as evidenced by estradiol receptors found in the heart, brain, bones, joints, skin, eyes, teeth, gums, nerves, blood vessels, urinary tract, reproductive organs, and more.

So, with estradiol depletion, a woman suffers the loss in countless ways, with deterioration of physical, mental, and emotional health that accompanies hormonal decline. Typically, a woman’s estradiol level starts to decline in her 40’s, and is almost undetectable by her early 50’s.
Estradiol replacement therapy relieves symptoms such as hot flashes, night sweats, insomnia, brain fog, moodiness, depression, vaginal dryness, painful intercourse, low libido, dry skin, and headaches. Health benefits from non-oral estradiol supplementation include reduced risk of cardiac disease and stroke, dementia, diabetes, and loss of bone density leading to osteoporosis.

What are Risks and Side Effects of Hormone Pellet Therapy for Women?

Hormone pellet insertion is a low risk procedure. A small percentage of women may experience a procedure related issue, such as infection, bleeding under the skin, or transient discomfort. Below is a discussion of potential risks and side effects related to the hormones of which pellets are composed.

Testosterone

Significant health risks of bioidentical testosterone therapy in women have not been identified. Any adverse health risk data you may have heard about would more likely be related to a synthetic oral drug called methyltestosterone, the only FDA approved testosterone available for females in the US, and a very different compound than bioidentical testosterone. Unfortunately, when disease risk related to hormone therapy is reported, authors commonly lump all “hormones” into one big pile, seemingly not recognizing that synthetic formulations are often much more potent, are not biochemically identical to each other or to our own natural hormones, and have different effects on the body than our natural hormones. Current data specifically regarding bioidentical testosterone formulations in women have not shown increased risk in cancer, cardiovascular disease, or other serious condition. In fact, numerous scientific studies suggest non-oral bioidentical testosterone may be breast protective, as well as protective of the heart, bones, and brain.

Testosterone pellet therapy is well tolerated; the majority of women report no side effects. A small number experience facial hair or acne, both of which can be managed by reducing the dose, or another specific solution. Often, the women who experience these side effects prefer to manage the issue rather than reduce their dose, a fact that reveals their satisfaction with therapeutic benefits received with testosterone therapy.

Estradiol

There has been much controversy and fear surrounding estrogen replacement therapy. Concerns about risk were largely generated from a 2002 study, the Women’s Health Initiative (WHI), which reported a small increase in breast cancer and cardiac risk. However, this study examined only one form of hormone, a 100% synthetic brand (Premarin+Provera), not a bioidentical hormone formulation. In addition, close analysis of the WHI, plus subsequent studies, have revealed the increase in cardiac risk was related to the fact that subjects had initiated hormone therapy in their mid 60’s, well past the menopausal transition, and they likely had pre-existing coronary artery plaques. It is now agreed among experts that if estrogen therapy is initiated early, within a few years of the menopausal transition, it is protective of the cardiovascular system, reducing development of coronary plaques, reducing inflammation, and lowering mortality. As for breast cancer, the WHI subjects who had increased incidence were taking a combination pill of synthetic estrogen (Premarin) + synthetic progestin (Provera). However, the subjects given estrogen with no progestin had reduced incidence of breast cancer. This and other studies demonstrates that the synthetic progestin component (not the estrogen component) of this particular hormone treatment seemed to be the responsible agent for breast cancer risk observed. In contrast, bioidentical progesterone is not associated with any health risk, and is safe to use alone or in conjunction with bioidentical estrogen.

Estradiol pellet therapy is well tolerated and convenient. Upon initiation, some women report transient breast swelling and tenderness, which if persistent can be managed with reduction of dose. Uterine bleeding is sometimes a transient issue, and there are often simple, nonsurgical solutions to manage this. A few women will have fluid retention with estradiol therapy, which can be managed by lowering the dose, or using a mild diuretic.

815-526-0326

Bioidentical Hormone Pellets

What is Bioidentical Hormone Pellet Therapy?

Testosterone Pellet Therapy:

Estradiol Pellet Therapy:

What are Risks and Side Effects of Hormone Pellet Therapy for Women?

Testosterone

Estradiol

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815-526-0326

815-526-0326

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